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1

Purification and catalytic properties of human caspase family members

Garcia-Calvo, Margarita, Peterson, Erin P, Rasper, Dita M, Vaillancourt, John P, Zamboni, Robert, Nicholson, Donald W, Thornberry, Nancy A

Journal:

Cell Death & Differentiation

Year:

1999

Language:

english

File:

PDF, 144 KB

english, 1999

2

Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

Marie Mancini, Carolyn E. Machamer, Sophie Roy, Donald W. Nicholson, Nancy A. Thornberry, Livia A. Casciola-Rosen and Antony Rosen

Journal:

The Journal of Cell Biology

Year:

2000

Language:

english

File:

PDF, 2.98 MB

english, 2000

3

Caspases: key mediators of apoptosis

Nancy A. Thornberry

Journal:

Chemistry & Biology

Year:

1998

Language:

english

File:

PDF, 4.63 MB

english, 1998

4

Human ICE/CED-3 Protease Nomenclature

Emad S Alnemri, David J Livingston, Donald W Nicholson, Guy Salvesen, Nancy A Thornberry, Winnie W Wong, Junying Yuan

Journal:

Year:

1996

Language:

english

File:

PDF, 90 KB

english, 1996

5

Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils

Darshak M Sanghavi, Marcus Thelen, Nancy A Thornberry, Livia Casciola-Rosen, Antony Rosen

Journal:

Year:

1998

Language:

english

File:

PDF, 248 KB

english, 1998

6

Heterocycle-Fused Cyclohexylglycine Derivatives as Novel Dipeptidyl Peptidase-IV Inhibitors.

Anthony Mastracchio, Emma R. Parmee, Barbara Leiting, Frank Marsilio, Reshma Patel, Nancy A. Thornberry, Ann E. Weber, Scott D. Edmondson

Journal:

Year:

2004

File:

PDF, 75 KB

2004

7

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design

Gui-Bai Liang, Xiaoxia Qian, Tesfaye Biftu, Suresh Singh, Ying-Duo Gao, Giovanna Scapin, Sangita Patel, Barbara Leiting, Reshma Patel, Joseph Wu, Xiaoping Zhang, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 427 KB

english, 2008

8

Interleukin-1βconverting enzyme: A novel cysteine protease required for IL-1β production and implicated in programmed cell death

Nancy A. Thornberry, Susan M. Molineaux

Journal:

Protein Science

Year:

1995

Language:

english

File:

PDF, 2.73 MB

english, 1995

9

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

Thornberry, Nancy A., Peterson, Erin P., Zhao, Justin J., Howard, Andrew D., Griffin, Patrick R., Chapman, Kevin T.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.37 MB

english, 1994

10

Identification of peptidase substrates in human plasma by FTMS based differential mass spectrometry

Nathan A. Yates, Ekaterina G. Deyanova, Wayne Geissler, Matthew C. Wiener, Jeffrey R. Sachs, Kenny K. Wong, Nancy A. Thornberry, Ranabir Sinha Roy, Robert E. Settlage, Ronald C. Hendrickson

Journal:

International Journal of Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 1.41 MB

english, 2007

11

A Synthetic Inhibitor of Interleukin-lβ Converting Enzyme Prevents Endotoxin-Induced Interleukin-lβ Production In Vitro and In Vivo

FLETCHER, DANIEL S., AGARWAL, LILY, CHAPMAN, KEVIN T., CHIN, JAYNE, EGGER, LINDA A., LIMJUCO, GUADALUPE, LUELL, SILVI, MacINTYRE, D. EUAN, PETERSON, ERIN P., THORNBERRY, NANCY A., KOSTURA, MATHEW J.

Journal:

Journal of Interferon & Cytokine Research

Year:

1995

Language:

english

File:

PDF, 2.00 MB

english, 1995

12

Diastereoselective Synthesis and Configuration-Dependent Activity of (3-Substituted-cycloalkyl)glycine Pyrrolidides and Thiazolidides as Dipeptidyl Peptidase IV Inhibitors.

Wallace T. Ashton, Hong Dong, Rosemary M. Sisco, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. Thornberry, Ann E. Weber

Journal:

Year:

2004

File:

PDF, 70 KB

2004

13

Activated ketones as potent reversible inhibitors of interleukin-Iβ converting enzyme

Adnan M.M. Mjalli, Kevin T. Chapman, Malcolm MacCoss, Nancy A. Thornberry, Erin P. Peterson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 188 KB

english, 1994

14

The IL-1β Converting Enzyme as a Therapeutic Target

DOUGLAS K. MILLER, JIMMY R. CALAYCAY, KEVIN T. CHAPMAN, ANDREW D. HOWARD, MATTHEW J. KOSTURA, SUSAN M. MOLINEAUX, NANCY A. THORNBERRY

Journal:

Annals of the New York Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.19 MB

english, 1993

15

Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors

Wallace T. Ashton, Hong Dong, Rosemary M. Sisco, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 241 KB

english, 2004

16

Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 Under Pathological Conditions

Shin-Jung Kang, Suyue Wang, Hideaki Hara, Erin P. Peterson, Shobu Namura, Sepideh Amin-Hanjani, Zhihong Huang, Anu Srinivasan, Kevin J. Tomaselli, Nancy A. Thornberry, Michael A. Moskowitz and Junying

Journal:

The Journal of Cell Biology

Year:

2000

Language:

english

File:

PDF, 3.22 MB

english, 2000

17

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

Marie Mancini, Donald W. Nicholson, Sophie Roy, Nancy A. Thornberry, Erin P. Peterson, Livia A. Casciola-Rosen and Antony Rosen

Journal:

The Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 2.90 MB

english, 1998

18

[Advances in Pharmacology] Apoptosls - Pharmacological Implications and Therapeutic Opportunities Volume 41 || Control of Apoptosis by Proteases

Thornberry, Nancy A.

Year:

1997

Language:

english

File:

PDF, 1.43 MB

english, 1997

19

Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole

Wallace T. Ashton, Rosemary M. Sisco, Hong Dong, Kathryn A. Lyons, Huaibing He, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 145 KB

english, 2005

20

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis

Christopher A. Willoughby, Herbert G. Bull, Margarita Garcia-Calvo, Joanne Jiang, Kevin T. Chapman, Nancy A. Thornberry

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

21

Interleukin-1β-converting enzyme and related proteases as potential targets in inflammation and apoptosis

Nancy A. Thornberry, Douglas K. Miller, Donald W. Nicholson

Journal:

Perspectives in Drug Discovery and Design

Year:

1995

Language:

english

File:

PDF, 784 KB

english, 1995

22

Caspases: killer proteases

Donald W. Nicholson, Nancy A. Thornberry

Journal:

Trends in Biochemical Sciences

Year:

1997

Language:

english

File:

PDF, 2.91 MB

english, 1997

23

Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII

LEITING, Barbara, PRYOR, KellyAnn D., WU, Joseph K., MARSILIO, Frank, PATEL, Reshma A., CRAIK, Charles S., ELLMAN, Jonathan A., CUMMINGS, Richard T., THORNBERRY, Nancy A.

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

24

A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE)

Thomas A. Rano, Tracy Timkey, Erin P. Peterson, Jennifer Rotonda, Donald W. Nicholson, Joseph W. Becker, Kevin T. Chapman, Nancy A. Thornberry

Journal:

Chemistry & Biology

Year:

1997

Language:

english

File:

PDF, 2.48 MB

english, 1997

25

Glucagon-like Peptide 1–Based Drugs and Pancreatic Safety

Brodovicz, Kimberly G., Engel, Samuel S., Thornberry, Nancy A.

Journal:

JAMA Internal Medicine

Year:

2013

Language:

english

File:

PDF, 70 KB

english, 2013

26

Nicotinyl aspartyl ketones as inhibitors of caspase-3

Elise Isabel, W.Cameron Black, Christopher I Bayly, Erich L Grimm, Marc K Janes, Daniel J McKay, Donald W Nicholson, Dita M Rasper, Johanne Renaud, Sophie Roy, John Tam, Nancy A Thornberry, John P Vai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

27

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Thornberry, Nancy A., Bull, Herbert G., Calaycay, Jimmy R., Chapman, Kevin T., Howard, Andrew D., Kostura, Matthew J., Miller, Douglas K., Molineaux, Susan M., Weidner, Jeffrey R., Aunins, John

Journal:

Year:

1992

File:

PDF, 1.24 MB

1992

28

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Jason M. Cox, Bart Harper, Anthony Mastracchio, Barbara Leiting, Ranabir Sinha Roy, Reshma A. Patel, Joseph K. Wu, Kathryn A. Lyons, Huaibing He, Shiyao Xu, Bing Zhu, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 160 KB

english, 2007

29

Inhibition of interleukin-1β converting enzyme by N-Acyl-aspartic acid ketones

Adnan M.M. Mjalli, Kevin T. Chapman, Justin J. Zhao, Nancy A. Thornberry, Erin P. Peterson, Malcolm MacCoss

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 190 KB

english, 1995

30

Phenylalkyl ketones as potent reversible inhibitors of interleukin-1β converting enzyme

Adnan M.M. Mjalli, Kevin T. Chapman, Malcolm MacCoss, Nancy A. Thornberry

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 210 KB

english, 1993

31

Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors

Ping Chen, Charles G. Caldwell, Wallace Ashton, Joseph K. Wu, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.35 MB

english, 2011

32

Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)

Nancy A. Thornberry, Baptist Gallwitz

Journal:

Best Practice & Research Clinical Endocrinology & Metabolism

Year:

2009

Language:

english

File:

PDF, 250 KB

english, 2009

33

Letters to the Editor

Joel Margolis, Mary Thornberry, Lewis A. Dexter, Richard E. Bissell, J. Michael Carmichael, Arnold Beichman, Sixto Carlos, Jr., Nancy Zingale and Mario A. Rivera

Journal:

Year:

1983

Language:

english

File:

PDF, 728 KB

english, 1983

34

Discovery of JANUVIA™ (Sitagliptin), a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type2 Diabetes.

Thornberry, Nancy, Weber, Ann

Journal:

Current Topics in Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 147 KB

english, 2007

35

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes

Ping Chen, Charles G. Caldwell, Robert J. Mathvink, Barbara Leiting, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 148 KB

english, 2007

36

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors

Jinyou Xu, Lan Wei, Robert Mathvink, Jiafang He, You-Jung Park, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Nancy A. Thornberry, Ann E. Weber

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

37

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Nicholson, Donald W., Ali, Ambereen, Thornberry, Nancy A., Vaillancourt, John P., Ding, Connie K., Gallant, Michel, Gareau, Yves, Griffin, Patrick R., Labelle, Marc, Lazebnik, Yuri A.

Journal:

Year:

1995

File:

PDF, 1.70 MB

1995

38

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents

Jonathan W. Day, Vasily Gelfanov, David Smiley, Paul E. Carrington, George Eiermann, Gary Chicchi, Mark D. Erion, Jas Gidda, Nancy A. Thornberry, Matthias H. Tschöp, Donald J. Marsh, Ranabir SinhaRoy,

Journal:

Year:

2012

Language:

english

File:

PDF, 504 KB

english, 2012

39

Adenovirus L4-100K Assembly Protein Is a Granzyme B Substrate that Potently Inhibits Granzyme B-Mediated Cell Death

Felipe Andrade, Herbert G Bull, Nancy A Thornberry, Gary W Ketner, Livia A Casciola-Rosen, Antony Rosen

Journal:

Year:

2001

Language:

english

File:

PDF, 369 KB

english, 2001

40

Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets

Deena Waddleton, Weizhen Wu, Yue Feng, Chris Thompson, Michael Wu, Yun-Ping Zhou, Andrew Howard, Nancy Thornberry, Jing Li, Joseph A. Mancini

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 659 KB

english, 2008

41

[Methods in Enzymology] Apoptosis Volume 322 || Determination of Caspase Specificities Using a Peptide Combinatorial Library

Thornberry, Nancy A.

Year:

2000

Language:

english

File:

PDF, 1.16 MB

english, 2000

42

ChemInform Abstract: Discovery of Potent, Selective Human Granzyme B Inhibitors That Inhibit CTL Mediated Apoptosis.

Christopher A. Willoughby, Herbert G. Bull, Margarita Garcia-Calvo, Joanne Jiang, Kevin T. Chapman, Nancy A. Thornberry

Journal:

Year:

2002

File:

PDF, 27 KB

2002

43

Inhibition of interleukin-1β converting enzyme by N-acyl-aspartyl aryloxymethyl ketones

Adnan M.M. Mjalli, Justin J. Zhao, Kevin T. Chapman, Nancy A. Thornberry, Erin P. Peterson, Malcolm MacCoss, William K. Hagmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 271 KB

english, 1995

44

Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors

Jinyou Xu, Hyun O. Ok, Edward J. Gonzalez, Lawrence F. Colwell Jr., Bahanu Habulihaz, Huaibing He, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Nancy A. Thornberry

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 258 KB

english, 2004

45

Kinetic Effects of ATP and Two Cellular Stimulatory Components on Human Leukocyte 5-Lipoxygenase

CAROL A. ROUZER, NANCY A. THORNBERRY, HERBERT G. BULL

Journal:

Annals of the New York Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 563 KB

english, 1988

46

Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors

Ying-Duo Gao, Dennis Feng, Robert P. Sheridan, Giovanna Scapin, Sangita B. Patel, Joseph K. Wu, Xiaoping Zhang, Ranabir Sinha-Roy, Nancy A. Thornberry, Ann E. Weber, Tesfaye Biftu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 182 KB

english, 2007

47

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

Jennifer Rotonda, Margarita Garcia-Calvo, Herb G Bull, Wayne M Geissler, Brian M McKeever, Christopher A Willoughby, Nancy A Thornberry, Joseph W Becker

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 1020 KB

english, 2001

48

Key mediator takes shape

Thornberry, Nancy A.

Journal:

Year:

1994

File:

PDF, 278 KB

1994

49

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes

James Mu, Aleksandr Petrov, George J. Eiermann, John Woods, Yun-Ping Zhou, Zhihua Li, Emanuel Zycband, Yue Feng, Lan Zhu, Ranabir Sinha Roy, Andrew D. Howard, Cai Li, Nancy A. Thornberry, Bei B. Zhang

Journal:

European Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 1.03 MB

english, 2009

50

Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

Felipe Andrade, Sophie Roy, Donald Nicholson, Nancy Thornberry, Antony Rosen, Livia Casciola-Rosen

Journal:

Year:

1998

Language:

english

File:

PDF, 271 KB

english, 1998

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